: 07.10.2002, 20:13:00










Bone marrow transplantation (BMT)


Related/unrelated allogeneic bone marrow transplantation is the most up-to-date and effective way of the treatment of many haematological, oncological and inherited diseases, including acute and chronic leukemia, immunodeficiency, lymphoma, anemias, neuroblastoma, metabolic disorders, and in some cases, solid tumors.
BMT procedure consists of several steps, such as collecting normal blood stem cells from healthy histoimmunologically matched donor out of bone marrow, peripheral blood, or umbilical cord blood "donor resources", executing any manipulations with these cells if needed, for example - additional cleaning transplant from unimportant cells and transfusing transplant to recipient. Once the healthy stem cells are get to the patient's blood stream, the cells migrate from the blood vessels inside the bones, where they begin to prolifirate to or to give the birth to new blood cells.
Hundreds of patients are registrated anew in Russia each year. Only BMT could save them.
For all patients of our hospital center only one treatment option is possible: bone marrow transplantation.

Peripheral blood (hematopoietic) stem cells donor database



   Hematopoietic stem cells derived
   from the bone marrow

Hematopoietic stem cells are the blood forming cells capable of producing all the components of blood immunological system and bone marrow. Cells capable of both self-renewal and differentiation to white blood cells, red blood cells, and platelets.
Cells histoimmunological capability is ability of the potential histoimmunologically compatible donor's cells match recipient's cells, so that they will not interact causing adverse reaction that may lead to the death.

Unfortunately, only 30% of patient have immunocompatible donor among their relatives.
Therefore, the rest of patients have to search for donor everywhere. In order to help such people survive every country creates its own blood marrow donors databases.
The databases of each country are united together into an international database.
This international registry contains data of more than 6 000 000 potential donors, but only about 80% of patients could find completely matching donor.
Because probability to find compatible donor is incredibly higher among the same ethnic group, Russia creates its own bone marrow transplant registry. One of the first who created the own bone marrow bank is I.Pavlov SpbMU.

The cofounders of our donor database: I.Pavlov SPbMU, Stefan Morsch Stiftung (German), International Association "Haematologists of the World for Children".

Bone marrow transplantation clinic


On June 22, 2000, a Russian-German clinic for bone marrow transplants equipped according to the international requirements was opened in St. Petersburg. The clinic is designated for performing related and unrelated transplantations for the patients from Northwest region and other regions of Russia. The co-founders of the clinic were St. Petersburg's Pavlov State Medical University and European Institute for Research and Development of Transplantation Strategies (EUFETS).
In October 2000, the first allogeneic unrelated bone marrow transplantation in Russia was performed in the clinic.

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Bone marrow transplantation clinic in SPbMU. Give the gift of life for somebody in Russia.





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