Related/unrelated allogeneic bone marrow transplantation is the most
up-to-date and effective way of the treatment
of many haematological, oncological and inherited diseases, including acute and chronic
leukemia, immunodeficiency, lymphoma, anemias, neuroblastoma, metabolic disorders,
and in some cases, solid tumors.
BMT procedure consists of several steps, such as collecting normal blood stem cells from healthy
histoimmunologically matched donor out of bone marrow, peripheral blood, or umbilical cord blood
"donor resources", executing any manipulations with these cells if needed, for example
- additional cleaning transplant from unimportant cells and transfusing transplant to recipient.
Once the healthy stem cells are get to the patient's blood stream, the cells migrate from the blood
vessels inside the bones, where they begin to prolifirate to or to give
the birth to new blood cells.
Hundreds of patients are registrated anew in Russia each year. Only BMT could save them.
For all patients of our hospital center only one treatment option is possible:
bone marrow transplantation.
Hematopoietic stem cells derived from the bone marrow
Hematopoietic stem cells are the blood forming cells capable of producing all the components
of blood immunological system and bone marrow. Cells capable of both self-renewal and differentiation
to white blood cells, red blood cells, and platelets.
Cells histoimmunological capability is ability of the potential histoimmunologically
compatible donor's cells match recipient's cells, so that they will not interact causing
adverse reaction that may lead to the death.
Unfortunately, only 30% of patient have immunocompatible donor among their relatives.
Therefore, the rest of patients have to search for donor everywhere. In order to help such
people survive every country creates its own blood marrow donors databases.
The databases of each country are united together into an international database.
This international registry contains data of more than 6 000 000 potential donors, but
only about 80% of patients could find completely matching donor.
Because probability to find compatible donor is incredibly higher among the same ethnic
group, Russia creates its own bone marrow transplant registry. One of the first who created the own bone
marrow bank is I.Pavlov SpbMU.
On June 22, 2000, a Russian-German clinic for bone marrow transplants
equipped according to the international requirements was opened in St.
Petersburg. The clinic is designated for performing related and unrelated
transplantations for the patients from Northwest region and other regions of Russia.
The co-founders of the clinic were St. Petersburg's Pavlov State
Medical University and European Institute for
Research and Development of Transplantation Strategies (EUFETS).
In October 2000, the first allogeneic unrelated bone marrow transplantation
in Russia was performed in the clinic.
We would be very grateful to everyone who can take the opportunity to
support treatment of the oncological patients and add our banner
to their web site. The visitors to your web site regardless of its topic will
appreciate your concern about ill children.
Please write us and we will
respond in kind. Here is a list of our partners.
